The Dr. Isidro Ferrer has initiated two research projects that seek to identify changes in brain precursors of Alzheimer's and Parkinson's

The research group of Dr. Isidro Ferrer, director of the Institute of Neuropathology at the University Hospital of Bellvitge, has initiated two research projects that seek to identify brain changes that are precursors of Alzheimer’s and Parkinson’s diseases.The study of Transcriptome Identification of risk in the first stages of Parkinson’s disease is one of IDIBELL projects that have received funding from Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III. The study on Alzheimer’s disease included in the project DEVELAGEPathways common to brain development and ageing ) of seven European research centers, has received funding from the 7th Framework Programme of the European Union.
The working hypothesis is that, in degenerative diseases of the nervous system can produce a process similar to atherosclerosis in cardiovascular diseases, ie, there may be progressive biological processes that for years  do not cause symptoms but finally express in degenerative neurological disease.
Factors such as the fact that up to 80% of people over 65 years have brain changes typical of Alzheimer’s, although only 5% actually have the disease, suggesting that this condition is actually a progressive degenerative process that starts at the years of 40 or 50.
From samples of brains from the Neurological Tissue Bank of IDIBELL, researchers will use sophisticated techniques to study the RNA, DNA, proteins, lipids and metabolites of the same brain region and, through computational studies, these results will be combined to obtain a molecular pattern of risk of developing the degenerative process.
The main objectives are to better understand the mechanisms that cause both diseases, search for preventive targets to stop or slow the degeneration before it appears, and look for markers that inform on aspects such as the rapidity of the degenerative process.
This research is a continuation of the work done in recent years at the Institute of Neuropathology, which includes, among other studies, tests with mice genetically engineered of some of the molecules already identified, with promising results.

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