On June 29th, Hospital Duran i Reynals hosted the workshop DNA Methylation: From Biology to Disease, where, after three years of working together, the European project CANCERDIP presented its final results.

The project was funded by the European Union under the 7th Framework Programme for Research and Development and coordinated by the Director of the Epigenetics and Biology of Cancer from IDIBELL, Manel Esteller.

End of CANCERDIP, a European project focused on deciphering the epigenetic changes that lead to cancer

The research was conducted in six centers from five European countries and has helped develop a new technique that has allowed the epigenomic mapping of more than 1,600 people.

According to the World Health Organization (WHO) more than seven million people die each year from cancer worldwide. This figure represents 13% of deaths worldwide.Besides genetic alterations, there are a growing number of epigenetic alterations that have become traits of the disease.

In this context, in January 2008 CANCERDIP project was born as a joint effort of the leading European groups in order to characterize the epigenetic mechanisms in cancer (especially regarding colon cancer and leukemia), and the mapping of the epigenetic modifications that lead to disease.

The results of this project will be used to generate various bioinformatic tools. The location of genomic DNA methylation, characteristics of the DNA sequence, and the presence of multiple epigenetic alterations will be used to generate a software to predict the epigenetic state of genes.

July 2011

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