Dr. Laura Calatayud, from  the Department of Microbiology of the HUB defended her doctoral thesis on  November 3rd. The thesis, entitled phenotypic and genotypic characterization of Streptococcus pneumoniae resistant to macrolides. Mechanisms of resistance and involved transposon , was directed by Dr. Josefina Linares and Dr. Carmen Ardanuy, and was given a grade of excellent cum laude unanimously.

Dr. Laura Calatayud, the Department of Microbiology, defended her doctoral thesis

The pneumococcus research began in the Microbiology Department in August 1978. The early works were based on the epidemiology of antibiotic resistance and serotypes. Later, after 1994, were introduced tipat molecular techniques that provided a better understanding of the epidemiology of pneumococcal disease.

The works that are part of this thesis have been carried out thanks to funding obtained from the Health Research Fund, and in the context of collaborative networks such as the Research Network on Neumococo and the CIBER of Respiratory Disease and have been published in prestigious journals.

The collaboration with the Infectious Diseases of the HUB has allowed the therapeutic and clinical-epidemiological necessary studies  to link the microbiological results with the clinical evolution of patients. They also had the collaboration of Microbiology services from other Spanish hospitals and the Reference Neumococo Laboratory of the National Centre of Microbiology.

The thesis studied the resistance patterns of pneumococcal strains over three decades, changes in the distribution of serotypes and genotypes, the mechanisms of resistance to macrolides, and coverage of various antipneumococciques vaccines

The study analyzed the importance of dissemination of emerging clones resistant to macrolides and the involvement of mobile genetic elements in the dissemination to the resistance to macrolides. And has studied the impact of the consumption of macrolides and the introduction of the heptavalent conjugate vaccine in children in the incidence of invasive pneumococcal disease in adults caused by strains resistant to macrolides.

The findings provide information on the mechanisms of resistance to macrolides in S.Pneumoniae in our country and its clinical impact in treating the disease, and on the impact of the use of conjugate vaccines and on the use of antibiotics in the resistance.

January 2012

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